Ertapenem is a broad-spectrum antibiotic used to treat serious bacterial infections. It belongs to the carbapenem class of antibiotics and is commonly prescribed in hospital settings for moderate to severe infections caused by susceptible bacteria.
Brand names such as Ernem and Invanz contain ertapenem as the active ingredient.
What Is Ertapenem Used For?
Ertapenem is used to treat various complicated bacterial infections, including:
- Intra-abdominal infections
- Complicated skin and soft tissue infections
- Complicated urinary tract infections (UTIs)
- Community-acquired pneumonia
- Acute pelvic infections
- Diabetic foot infections (without bone involvement)
It is effective against many gram-positive and gram-negative bacteria but does not cover certain hospital-acquired pathogens like Pseudomonas.
How Ertapenem Works
Ertapenem works by inhibiting bacterial cell wall synthesis. It binds to specific penicillin-binding proteins (PBPs), leading to bacterial cell death. Because of its broad spectrum, it is often reserved for serious or resistant infections.
Dosage & Administration
- Adults: Usually 1 gram once daily
- Children (3 months to 12 years): 15 mg/kg twice daily (maximum 1 gram/day)
- Administered via intravenous (IV) or intramuscular (IM) injection
- Duration typically ranges from 5 to 14 days depending on infection severity
Dosage adjustments may be required in patients with kidney impairment.
Side Effects
Like all antibiotics, ertapenem may cause side effects, including:
- Diarrhea
- Nausea or vomiting
- Headache
- Injection site reactions
- Mild liver enzyme elevation
Serious but rare side effects may include allergic reactions or seizures, especially in patients with CNS disorders.
Warnings & Precautions
- Not effective against viral infections
- Use cautiously in patients with seizure history
- Dose adjustment required in renal impairment
- Complete the full prescribed course to prevent resistance
Frequently Asked Questions (FAQs)
Q: What is Ertapenem used for?
A: It is used to treat serious bacterial infections such as complicated UTIs, abdominal infections, pneumonia, and skin infections.
Q: Is Ertapenem a strong antibiotic?
A: Yes, it is a broad-spectrum carbapenem antibiotic usually reserved for moderate to severe infections.
Q: How is Ertapenem administered?
A: It is given through IV or IM injection, typically once daily.
Q: Can Ertapenem cause diarrhea?
A: Yes, mild gastrointestinal side effects like diarrhea may occur.
Q: Is Ertapenem safe during pregnancy?
A: It should only be used during pregnancy if clearly needed and prescribed by a healthcare professional.
Final Thoughts
Ertapenem (Ernem & Invanz) is an effective treatment option for complicated bacterial infections. Because it is a powerful antibiotic, it should only be used under medical supervision to ensure safety and prevent antibiotic resistance.