Virbeg 75mg Tablet contains Vibegron, a highly selective β3-adrenergic receptor agonist that helps control symptoms of Overactive Bladder (OAB) such as urgency, frequent urination, and urge incontinence.

It provides superior control and comfort by relaxing the detrusor muscle during the bladder filling phase, allowing the bladder to store urine more effectively.

Efficacy & Safety (COURAGE Trial)

In a randomized controlled COURAGE trial, Vibegron was assessed among men with persistent OAB symptoms who were already receiving pharmacologic treatment for Benign Prostatic Hyperplasia (BPH).

• Vibegron showed significant reductions vs placebo in mean daily micturitions and urgency episodes.

• Participants with ≥50% reduction in daily urgency episodes: higher response compared to placebo at every measured week.

• Well-tolerated and safe for use in men with OAB symptoms treated pharmacologically for BPH.

Selectivity & Maximum Response

Vibegron demonstrates maximum β3-adrenergic receptor response of 99.2%, compared to 80.4% with Mirabegron, indicating stronger and more selective action with minimal off-target effects.

This superior selectivity enhances both efficacy and patient tolerability.

Comparative Efficacy (vs. Mirabegron)

A systematic review and network meta-analysis of 11 randomized controlled trials (n=10,086) concluded that:

• Vibegron was more efficacious than Mirabegron in reducing mean voided volume/micturition frequency.

• 95% efficacy rate achieved in clinical evaluations.

Clinical Benefits

✅ Rapid symptom relief for urgency and frequency

✅ Better bladder capacity and reduced nocturia

✅ Minimal adverse effects and drug interactions

✅ Safe for men with OAB and BPH under pharmacologic therapy

Dosage & Administration

• Recommended dose: 75mg once daily, with or without food

• Route: Oral

• Do not exceed prescribed dosage without consulting a physician

Precautions

• Use under medical supervision in patients with renal or hepatic impairment

• Inform your doctor about all current medications before starting Virbeg

• Not recommended for pediatric use