Grasil Injection 250mg/2mL contains Amikacin Sulphate, a broad‑spectrum aminoglycoside antibiotic used to treat serious bacterial infections caused by susceptible strains, especially in hospital or clinical settings.

Amikacin works by inhibiting bacterial protein synthesis, which stops bacteria from growing and replicating. It is especially effective against gram‑negative bacteria and is often reserved for use when other antibiotics are ineffective or when resistant organisms are suspected. The injectable form ensures rapid delivery and high blood levels of the antibiotic, making it suitable for severe systemic infections.

This medicine must be administered by a trained healthcare professional under strict medical supervision due to required dosing precision and monitoring.

Uses

• Treatment of severe urinary tract infections (UTIs)

• Management of sepsis (bloodstream infections)

• Treatment of hospital‑acquired pneumonia

• Management of bone and joint infections (osteomyelitis)

• Treatment of intra‑abdominal infections

• Effective against multi‑drug‑resistant gram‑negative bacteria

Benefits

• Provides powerful action against serious infections

• Effective against aminoglycoside‑sensitive gram‑negative bacteria

• Rapid onset with injectable administration

• Useful where other antibiotics fail

• Supports treatment of life‑threatening infections

Prescription Required: Yes

Generic Name: Amikacin Sulphate

Use: Treatment of severe bacterial infections

How It Works

Amikacin binds to the bacterial 30S ribosomal subunit, disrupting protein synthesis. This action prevents bacteria from producing essential proteins, leading to bacterial death and infection control.

Dosage

• Adults: Dosing is typically 15 mg/kg/day given in divided doses or as once‑daily infusion per doctor’s prescription.

• Children: Dose calculated based on weight and clinical condition.

• Administered as intravenous (IV) infusion or intramuscular (IM) injection.

• Dose and duration vary depending on infection type and patient factors.

• Must be given by a healthcare professional.

Common Side Effects

• Pain or irritation at injection site

• Kidney toxicity (nephrotoxicity)

• Hearing loss or balance issues (ototoxicity)

• Rash or itching

• Nausea

Because of potential nerve and ear toxicity, regular monitoring of kidney function and hearing is essential during treatment.

Drug Interactions

• Loop diuretics (e.g., furosemide) — increased ototoxicity risk

• Other nephrotoxic drugs (e.g., vancomycin)

• Muscle relaxants — may enhance effects

• General anesthesia agents — caution advised

Always inform the healthcare provider of all current medications.

Do Not Use If

• Allergy to Amikacin or aminoglycosides

• Pre‑existing kidney disease without specialist supervision

• Hearing or balance disorders

• Pregnancy or breastfeeding unless clearly prescribed

Storage

Store at room temperature (20–25°C), away from direct sunlight and moisture. Keep out of reach of children. The vial must be used promptly after opening according to clinical protocols.

FAQs

Q1: What is Grasil Injection 250mg/2mL used for?

It’s used to treat serious bacterial infections including UTIs, sepsis, and hospital‑acquired pneumonia.

Q2: Who should administer this injection?

Only trained healthcare professionals should administer it in a clinical setting.

Q3: How does Amikacin work?

It disrupts bacterial protein synthesis, leading to bacterial death.

Q4: Can Grasil cause kidney problems?

Yes, nephrotoxicity is a possible side effect; monitoring is needed.

Q5: Can it cause hearing loss?

Yes, ototoxicity (hearing/balance issues) can occur — especially with prolonged use.

Q6: Is it safe during pregnancy?

Use only if clearly needed and prescribed by a doctor after evaluation.

Q7: What should be monitored during treatment?

Doctors monitor kidney function and hearing regularly.