Glucovance 250mg/1.25mg Tablet is a combination oral antidiabetic medicine containing Metformin 250mg and Glibenclamide 1.25mg. It is used to improve blood glucose control in people with Type 2 diabetes mellitus when diet and exercise alone are not sufficient.

Metformin helps reduce glucose production by the liver and improves the body's response to insulin, while glibenclamide stimulates the pancreas to release insulin. Together, these medicines help lower elevated blood glucose levels.

A commonly listed Pakistani presentation contains 30 tablets (2 × 15).

Uses

• Management of Type 2 diabetes mellitus
• Helps control high blood sugar
• Improves glucose utilization
• Helps reduce glucose production by the liver
• May be prescribed when diet, exercise or single-drug therapy does not provide adequate control

Benefits

• Combines two blood-sugar-lowering medicines
• Helps improve glycemic control
• Metformin improves insulin sensitivity
• Glibenclamide stimulates insulin release
• Convenient tablet formulation

Composition

Each tablet contains:

• Metformin Hydrochloride — 250mg
• Glibenclamide — 1.25mg

Glibenclamide is also known internationally as glyburide.

Dosage

• Take Glucovance exactly as prescribed by your doctor.
• It is generally taken with meals.
• Take it at the same time each day as directed.
• Do not skip meals after taking glibenclamide-containing medicine because it can increase the risk of low blood sugar.
• Do not change the dose without medical advice.

Possible Side Effects

Possible side effects include:

• Nausea
• Vomiting
• Diarrhea
• Stomach discomfort
• Abdominal pain
• Weakness
• Dizziness
• Metallic taste
• Low blood sugar (hypoglycemia)

Because glibenclamide increases insulin release, hypoglycemia is an important potential adverse effect.

Precautions

• Use only under the supervision of a healthcare professional.
• Tell your doctor if you have kidney or liver disease.
• Inform your doctor if you have a history of severe or recurrent hypoglycemia.
• Avoid excessive alcohol consumption.
• Monitor blood glucose regularly as recommended.
• Tell your doctor about all medicines and supplements you use.
• Seek urgent medical attention for severe weakness, confusion, sweating, shaking or loss of consciousness, which may indicate severe hypoglycemia.
• Metformin can rarely cause serious lactic acidosis, particularly in people with significant kidney impairment or certain other risk factors.

Price in Pakistan

Current online pharmacy listings show varying prices depending on the seller and presentation. For the commonly listed 2 × 15 tablet pack, Servaid lists Rs. 63.60, while other Pakistani pharmacies currently list different prices.

For your Mr Medicine Mart product page, I recommend displaying the current Mr Medicine Mart selling price rather than a fixed market-wide price, because pharmacy prices can change.

FAQs

Q1: What is Glucovance 250mg/1.25mg used for?

Glucovance is used to help control blood sugar in people with Type 2 diabetes mellitus.

Q2: What are the ingredients in Glucovance?

Each tablet contains Metformin 250mg and Glibenclamide 1.25mg.

Q3: Is Glucovance used for Type 1 diabetes?

No. Glucovance is intended for Type 2 diabetes and is not a replacement for insulin in Type 1 diabetes.

Q4: Can Glucovance cause low blood sugar?

Yes. Glibenclamide can cause hypoglycemia, particularly if meals are skipped or the medicine is taken in a higher dose than prescribed.

Q5: Should Glucovance be taken with food?

Yes. Taking it with meals as directed can improve gastrointestinal tolerance and helps reduce the risk of hypoglycemia associated with glibenclamide.