Tofacitinib is a prescription medicine that belongs to a class of drugs called Janus kinase (JAK) inhibitors. It works by reducing inflammation in the body and is commonly used for autoimmune conditions.
Uses of Tofacitinib
Tofacitinib is used to treat:
- Rheumatoid Arthritis (RA)
- Psoriatic Arthritis (PsA)
- Ulcerative Colitis (UC)
- Ankylosing Spondylitis (AS)
- Juvenile Idiopathic Arthritis (JIA) (in certain cases)
It helps reduce pain, swelling, joint damage, and other inflammatory symptoms.
Dosage
The dosage depends on the condition being treated:
- Rheumatoid Arthritis / Psoriatic Arthritis: 5 mg twice daily
- Ulcerative Colitis: 10 mg twice daily (initially), then reduced to 5 mg twice daily
- Extended-release tablets: 11 mg once daily (as prescribed)
Always follow your doctor’s prescription. Do not adjust dosage without medical advice.
Warnings & Precautions
Before taking Tofacitinib, inform your doctor if you have:
- History of infections (TB, hepatitis)
- Liver or kidney disease
- Heart disease
- History of blood clots
- Cancer history
- Weakened immune system
Serious Risks May Include:
- Serious infections
- Blood clots
- Heart-related problems
- Increased risk of certain cancers
Regular blood tests are usually required during treatment.
Side Effects
Common side effects:
- Headache
- Diarrhea
- Nausea
- Upper respiratory infections
- Increased cholesterol levels
Serious side effects (seek medical help immediately):
- Chest pain
- Shortness of breath
- Severe infections
-
Unusual bruising or bleeding
Available Brands In PakistanÂ
Several pharmaceutical brands market Tofacitinib in Pakistan and internationally. These available formulations contain the same active ingredient (Tofacitinib) and are used for the same clinical indications — the main differences being manufacturing source, packaging, price, and approval approvals.
Common Available Brands
| Brand Name | Country/Region | Formulation |
| Tofajak | Pakistan / Local | 5 mg Tablet |
| Xeljanz | Global (Original Brand) | 5 mg Tablet, 11 mg Extended-Release |
| Tofacent | Local / Regional | 5 mg Tablet |
| Tofanib | Local / Regional | 5 mg Tablet |
FAQs
Q: What is Tofacitinib used for?
A: Tofacitinib is used to treat rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, ankylosing spondylitis, and certain types of juvenile arthritis. It reduces inflammation and immune system overactivity.
Q: Who can use Tofacitinib?
A: Adults diagnosed with autoimmune inflammatory conditions can use Tofacitinib if prescribed by a doctor. It may also be used in certain children with juvenile idiopathic arthritis under medical supervision.
Q: How to use Tofacitinib?
A: Take Tofacitinib exactly as prescribed by your doctor, usually once or twice daily with or without food. Swallow tablets whole with water. Do not crush or chew extended-release tablets.
Q: Is Tofacitinib safe?
A: Tofacitinib is safe when used under medical supervision. However, it may increase the risk of infections, blood clots, or heart-related issues in some patients. Regular monitoring is important.
Q: What are the side effects of Tofacitinib?
A: Common side effects include headache, diarrhea, nausea, and infections. Serious side effects are rare but may include blood clots, serious infections, or heart problems.
Q: Are there alternatives to Tofacitinib?
A: Yes, alternatives include other biologic or immunosuppressive medications such as methotrexate, adalimumab, and other JAK inhibitors. Your doctor can recommend the best option based on your condition.
Q: Is Tofacitinib available in Pakistan?
A: Yes it's Available at Mr Medicine Mart in Pakistan, Home Delivery Available with Best Prices.
Disclaimer: This information is for educational purposes only and does not replace professional medical advice. Always consult a qualified healthcare provider before starting or stopping any medication.