What is Paricalcitol?
Paricalcitol, commonly available under the brand name Parical, is a synthetic form of vitamin D. It is mainly used to manage secondary hyperparathyroidism in patients suffering from chronic kidney disease (CKD), especially those on dialysis.
This medicine helps regulate parathyroid hormone (PTH) levels without causing excessive calcium absorption, making it safer than some older vitamin D therapies.
Uses
Paricalcitol is primarily prescribed for:
- Treatment of secondary hyperparathyroidism
- Patients with chronic kidney disease (Stage 3, 4, or 5)
- CKD patients on hemodialysis or peritoneal dialysis
- Preventing bone disorders related to kidney disease
It helps maintain proper bone health by controlling abnormal PTH levels.
How Paricalcitol Works
In kidney disease, the body cannot activate vitamin D properly, which leads to increased parathyroid hormone levels.
Paricalcitol works by:
- Activating vitamin D receptors
- Suppressing excess PTH secretion
- Reducing the risk of bone pain, fractures, and cardiovascular complications
Dosage
The dosage of Paricalcitol depends on:
- Severity of kidney disease
- PTH levels
- Whether the patient is on dialysis
General Dosage Guidelines
- Oral capsules: Taken once daily or as prescribed
- Injection form: Administered during dialysis sessions
Important: Dosage should always be determined by a healthcare professional. Do not self-adjust the dose.
How to Take Paricalcitol
- Take the medicine exactly as prescribed
- Can be taken with or without food
- Do not skip doses or double the dose if one is missed
- Regular blood tests may be required to monitor calcium and PTH levels
Side Effects
Like all medicines, Paricalcitol may cause side effects, though not everyone experiences them.
Common Side Effects
- Nausea
- Vomiting
- Headache
- Dizziness
Less Common but Serious Side Effects
- High calcium levels (hypercalcemia)
- Muscle weakness
- Irregular heartbeat
- Confusion
If any severe or unusual symptoms occur, consult a doctor immediately.
Warnings & Precautions
- Not recommended in patients with high calcium levels
- Use cautiously in patients with heart disease
- Inform your doctor about all medicines and supplements you are taking
- Regular monitoring of calcium, phosphorus, and PTH levels is essential
Drug Interactions
Paricalcitol may interact with:
- Calcium supplements
- Phosphate binders
- Other vitamin D analogues
Always inform your healthcare provider about your complete medication list.
Frequently Asked Questions (FAQs)
What is Paricalcitol used for?
Paricalcitol is used to treat secondary hyperparathyroidism in patients with chronic kidney disease.
Who can use Paricalcitol?
Adults with CKD, especially those on dialysis, can use it under medical supervision.
How long does Paricalcitol take to work?
It gradually reduces PTH levels over a few weeks, depending on the dose and patient condition.
Is Paricalcitol safe for long-term use?
Yes, when used under medical supervision with regular blood monitoring.
What are the main side effects of Paricalcitol?
Common side effects include nausea and headache, while serious effects may include high calcium levels.
Is Parical (Paricalcitol) available in Pakistan?
Yes, Parical (Paricalcitol) is available in Pakistan at Mr Medicine Mart, with home delivery and best market-competitive prices.